4PUQ

Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+

Summary for 4PUQ

• Entry DOI: 10.2210/pdb4puq/pdb
• Related: 4GZ1
• Descriptor: Tyrosyl-DNA phosphodiesterase 2, DNA/RNA hybrid, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: protein-dna complex, dna repair, 5'-dna end processing, eep domain, hydrolase, metalloenzyme, 5'-dna end recognition, hydrolase-dna-rna complex, hydrolase/dna/rna
• Biological source: Mus musculus (mouse); More
• Cellular location: Nucleus (By similarity): Q9JJX7
• Total number of polymer chains: 4
• Total formula weight: 63627.85

Authors

Schellenberg, M.J.,Williams, R.S. (deposition date: 2014-03-13, release date: 2014-05-14, Last modification date: 2023-09-20)

• Primary citation: Gao, R.,Schellenberg, M.J.,Huang, S.Y.,Abdelmalak, M.,Marchand, C.,Nitiss, K.C.,Nitiss, J.L.,Williams, R.S.,Pommier, Y.; Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).; J.Biol.Chem., 289:17960-17969, 2014; PubMed: 24808172; DOI: 10.1074/jbc.M114.565374

Experimental method

X-RAY DIFFRACTION (1.6 Å)