4PGZ

Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation

Summary for 4PGZ

Entry DOI	10.2210/pdb4pgz/pdb
Descriptor	Mast/stem cell growth factor receptor Kit, 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, ... (4 entities in total)
Functional Keywords	receptor tyrosine kinase, kit receptor, igsf, cancer, surface receptor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	71050.96
Authors	Reshetnyak, A.V.,Boggon, T.J.,Lax, I.,Schlessinger, J. (deposition date: 2014-05-03, release date: 2015-03-18, Last modification date: 2023-12-27)
Primary citation	Reshetnyak, A.V.,Opatowsky, Y.,Boggon, T.J.,Folta-Stogniew, E.,Tome, F.,Lax, I.,Schlessinger, J. The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. Mol.Cell, 57:191-201, 2015 Cited by PubMed: 25544564 DOI: 10.1016/j.molcel.2014.11.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation