Summary for 6OP9
| Entry DOI | 10.2210/pdb6op9/pdb |
| Descriptor | Receptor tyrosine-protein kinase erbB-3, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile (3 entities in total) |
| Functional Keywords | receptor tyrosine kinase, pseudokinase, bosutinib, membrane, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 37472.37 |
| Authors | Littlefield, P.,Agnew, C.,Jura, N. (deposition date: 2019-04-24, release date: 2019-08-21, Last modification date: 2022-02-16) |
| Primary citation | Campbell, M.R.,Ruiz-Saenz, A.,Peterson, E.,Agnew, C.,Ayaz, P.,Garfinkle, S.,Littlefield, P.,Steri, V.,Oeffinger, J.,Sampang, M.,Shan, Y.,Shaw, D.E.,Jura, N.,Moasser, M.M. Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers. Cell Rep, 38:110291-110291, 2022 Cited by PubMed: 35108525DOI: 10.1016/j.celrep.2021.110291 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.501 Å) |
Structure validation
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