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4OQ5

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

Summary for 4OQ5
Entry DOI10.2210/pdb4oq5/pdb
Related4OQ6
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1, 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid (3 entities in total)
Functional Keywordsapoptosis-inhibitor complex, apoptosis/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass membrane protein (Potential): Q07820
Total number of polymer chains6
Total formula weight114100.31
Authors
Petros, A.M.,Swann, S.L.,Song, D.,Swinger, K.,Park, C.,Zhang, H.,Wendt, M.D.,Kunzer, A.R.,Souers, A.J.,Sun, C. (deposition date: 2014-02-07, release date: 2014-03-12, Last modification date: 2024-02-28)
Primary citationPetros, A.M.,Swann, S.L.,Song, D.,Swinger, K.,Park, C.,Zhang, H.,Wendt, M.D.,Kunzer, A.R.,Souers, A.J.,Sun, C.
Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24:1484-1488, 2014
Cited by
PubMed: 24582986
DOI: 10.1016/j.bmcl.2014.02.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.86 Å)
Structure validation

217705

數據於2024-03-27公開中

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