4OGE

Crystal structure of the Type II-C Cas9 enzyme from Actinomyces naeslundii

Summary for 4OGE

Entry DOI	10.2210/pdb4oge/pdb
Related	4CMP 4CMQ 4OGC
Descriptor	HNH endonuclease domain protein, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	crispr-cas, cas9, hnh, ruvc, rna-guided dna endonuclease, cytoplasmic, hydrolase
Biological source	Actinomyces naeslundii
Total number of polymer chains	1
Total formula weight	124387.52
Authors	Jiang, F.,Ma, E.,Lin, S.,Doudna, J.A. (deposition date: 2014-01-15, release date: 2014-02-12, Last modification date: 2024-02-28)
Primary citation	Jinek, M.,Jiang, F.,Taylor, D.W.,Sternberg, S.H.,Kaya, E.,Ma, E.,Anders, C.,Hauer, M.,Zhou, K.,Lin, S.,Kaplan, M.,Iavarone, A.T.,Charpentier, E.,Nogales, E.,Doudna, J.A. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, 343:1247997-1247997, 2014 Cited by PubMed: 24505130 DOI: 10.1126/science.1247997 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.201 Å)

Structure validation