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4OBA

Co-crystal structure of MDM2 with Inhibitor Compound 4

Summary for 4OBA
Entry DOI10.2210/pdb4oba/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (3 entities in total)
Functional Keywordsp53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains3
Total formula weight35173.68
Authors
Shaffer, P.L.,Huang, X.,Yakowec, P.,Long, A.M. (deposition date: 2014-01-07, release date: 2014-03-19, Last modification date: 2023-09-20)
Primary citationGonzalez, A.Z.,Eksterowicz, J.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Duquette, J.,Fox, B.M.,Fu, J.,Huang, X.,Houze, J.B.,Jin, L.,Li, Y.,Li, Z.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,McMinn, D.L.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Medina, J.C.,Sun, D.
Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.
J.Med.Chem., 57:2472-2488, 2014
Cited by
PubMed: 24548297
DOI: 10.1021/jm401767k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.602 Å)
Structure validation

217705

數據於2024-03-27公開中

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