Summary for 4O6W
| Entry DOI | 10.2210/pdb4o6w/pdb |
| Related PRD ID | PRD_001173 |
| Descriptor | Serine/threonine-protein kinase PLK1, Peptide-Based inhibitor (3 entities in total) |
| Functional Keywords | polo box domain, phospho-peptide binding, phosphopeptide, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: P53350 |
| Total number of polymer chains | 2 |
| Total formula weight | 28220.21 |
| Authors | Qian, W.-J.,Park, J.-E.,Lim, D.C.,Park, S.-Y.,Lee, K.-W.,Yaffe, M.B.,Lee, K.S.,Burke, T.R. (deposition date: 2013-12-23, release date: 2014-12-03) |
| Primary citation | Qian, W.J.,Park, J.E.,Lim, D.,Lai, C.C.,Kelley, J.A.,Park, S.Y.,Lee, K.W.,Yaffe, M.B.,Lee, K.S.,Burke, T.R. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells. Biopolymers, 102:444-455, 2014 Cited by PubMed: 25283071DOI: 10.1002/bip.22569 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.448 Å) |
Structure validation
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