4O4L

Tubulin-Peloruside A-Epothilone A complex

Summary for 4O4L

Entry DOI	10.2210/pdb4o4l/pdb
Related	4O4H 4O4I 4O4J
Descriptor	Tubulin alpha-1B chain, EPOTHILONE A, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (12 entities in total)
Functional Keywords	alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, peloruside a, epothilone a, tubulin fold, cytoskeleton, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Rattus norvegicus (rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043
Total number of polymer chains	6
Total formula weight	266061.41
Authors	Prota, A.E.,Bargsten, K.,Northcote, P.T.,Marsh, M.,Altmann, K.H.,Miller, J.H.,Diaz, J.F.,Steinmetz, M.O. (deposition date: 2013-12-18, release date: 2014-03-26, Last modification date: 2024-04-03)
Primary citation	Prota, A.E.,Bargsten, K.,Northcote, P.T.,Marsh, M.,Altmann, K.H.,Miller, J.H.,Diaz, J.F.,Steinmetz, M.O. Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew.Chem.Int.Ed.Engl., 53:1621-1625, 2014 Cited by PubMed: 24470331 DOI: 10.1002/anie.201307749 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation