4NYJ

Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange

Summary for 4NYJ

• Entry DOI: 10.2210/pdb4nyj/pdb
• Descriptor: GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: gtpase, signaling transduction, raf, ralgds, pi3k, cytosol, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane. Isoform 2: Nucleus: P01112 P01112
• Total number of polymer chains: 3
• Total formula weight: 95023.89

Authors

Burns, M.C.,Sun, Q.,Phan, J.,Fesik, S.W. (deposition date: 2013-12-10, release date: 2014-03-12, Last modification date: 2023-09-20)

• Primary citation: Burns, M.C.,Sun, Q.,Daniels, R.N.,Camper, D.,Kennedy, J.P.,Phan, J.,Olejniczak, E.T.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.; Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.; Proc.Natl.Acad.Sci.USA, 111:3401-3406, 2014; PubMed: 24550516; DOI: 10.1073/pnas.1315798111

Experimental method

X-RAY DIFFRACTION (2.8522 Å)