4NVQ

Human G9a in Complex with Inhibitor A-366

Summary for 4NVQ

• Entry DOI: 10.2210/pdb4nvq/pdb
• Descriptor: Histone-lysine N-methyltransferase EHMT2, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• Functional Keywords: lysine methyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q96KQ7
• Total number of polymer chains: 2
• Total formula weight: 67699.51

Authors

Sweis, R.F.,Pliushchev, M.,Brown, P.J.,Guo, J.,Li, F.,Maag, D.,Petros, A.M.,Soni, N.B.,Tse, C.,Vedadi, M.,Michaelides, M.R.,Chiang, G.G.,Pappano, W.N. (deposition date: 2013-12-05, release date: 2014-01-15, Last modification date: 2024-02-28)

• Primary citation: Sweis, R.F.,Pliushchev, M.,Brown, P.J.,Guo, J.,Li, F.,Maag, D.,Petros, A.M.,Soni, N.B.,Tse, C.,Vedadi, M.,Michaelides, M.R.,Chiang, G.G.,Pappano, W.N.; Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.; ACS Med Chem Lett, 5:205-209, 2014; PubMed: 24900801; DOI: 10.1021/ml400496h

Experimental method

X-RAY DIFFRACTION (2.03 Å)