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4NQL

The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin

Summary for 4NQL
Entry DOI10.2210/pdb4nql/pdb
Related2ZNV 3RZV 4MSM 4MSQ
DescriptorAMSH-like protease sst2, Ubiquitin, ZINC ION, ... (6 entities in total)
Functional Keywordsjamm domain, zinc metalloprotease, protein complex, amsh, heix-beta-helix sandwich, hydrolase, metal binding, k63-linked diubiquitin, helix-beta-helix sandwich, deubiquitinase, ubiquitin, hse1, cytosol, endosome, hydrolase-protein binding complex, hydrolase/protein binding
Biological sourceSchizosaccharomyces pombe (Fission yeast)
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Cellular locationCytoplasm: Q9P371
Cytoplasm (By similarity): P0CG50 P0CG50
Total number of polymer chains3
Total formula weight42457.62
Authors
Ronau, J.A.,Shrestha, R.K.,Das, C. (deposition date: 2013-11-25, release date: 2014-10-08, Last modification date: 2024-01-10)
Primary citationShrestha, R.K.,Ronau, J.A.,Davies, C.W.,Guenette, R.G.,Strieter, E.R.,Paul, L.N.,Das, C.
Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product.
Biochemistry, 53:3199-3217, 2014
Cited by
PubMed: 24787148
DOI: 10.1021/bi5003162
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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