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4NJU

Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with tipranavir

Summary for 4NJU
Entry DOI10.2210/pdb4nju/pdb
Related4NJS 4NJT 4NJV
DescriptorProtease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE (3 entities in total)
Functional Keywordsmultidrug-resistance, hiv-1 protease, tipranavir, tpv, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains4
Total formula weight44660.32
Authors
Yedidi, R.S.,Garimella, H.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Mitsuya, H. (deposition date: 2013-11-11, release date: 2014-04-02, Last modification date: 2024-02-28)
Primary citationYedidi, R.S.,Garimella, H.,Aoki, M.,Aoki-Ogata, H.,Desai, D.V.,Chang, S.B.,Davis, D.A.,Fyvie, W.S.,Kaufman, J.D.,Smith, D.W.,Das, D.,Wingfield, P.T.,Maeda, K.,Ghosh, A.K.,Mitsuya, H.
A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58:3679-3688, 2014
Cited by
PubMed: 24752271
DOI: 10.1128/AAC.00107-14
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

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