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4NJT

Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir

Summary for 4NJT
Entry DOI10.2210/pdb4njt/pdb
Related4HLA 4NJS 4NJU 4NJV
DescriptorProtease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
Functional Keywordsmultidrug-resistance, hiv-1 protease, darunavir, non-peptidic inhibitor, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains4
Total formula weight44726.44
Authors
Yedidi, R.S.,Garimella, H.,Chang, S.B.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2013-11-11, release date: 2014-04-02, Last modification date: 2024-02-28)
Primary citationYedidi, R.S.,Garimella, H.,Aoki, M.,Aoki-Ogata, H.,Desai, D.V.,Chang, S.B.,Davis, D.A.,Fyvie, W.S.,Kaufman, J.D.,Smith, D.W.,Das, D.,Wingfield, P.T.,Maeda, K.,Ghosh, A.K.,Mitsuya, H.
A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58:3679-3688, 2014
Cited by
PubMed: 24752271
DOI: 10.1128/AAC.00107-14
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

건을2024-03-27부터공개중

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