4NFF

Human kallikrein-related peptidase 2 in complex with PPACK

Summary for 4NFF

• Entry DOI: 10.2210/pdb4nff/pdb
• Related: 4NFE
• Related PRD ID: PRD_000020
• Descriptor: Kallikrein-2, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide (3 entities in total)
• Functional Keywords: chymotrypsin-like protease, zinc binding, extracellular, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 26644.92

Authors

Skala, W.,Brandstetter, H.,Magdolen, V.,Goettig, P. (deposition date: 2013-10-31, release date: 2014-10-29, Last modification date: 2017-11-15)

• Primary citation: Skala, W.,Utzschneider, D.T.,Magdolen, V.,Debela, M.,Guo, S.,Craik, C.S.,Brandstetter, H.,Goettig, P.; Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity; J.Biol.Chem., 289:34267-34283, 2014; PubMed: 25326387; DOI: 10.1074/jbc.M114.598201

Experimental method

X-RAY DIFFRACTION (1.9 Å)