4NCA

Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+

Summary for 4NCA

• Entry DOI: 10.2210/pdb4nca/pdb
• Related: 4N41 4N47 4N76 4NCB
• Descriptor: Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ... (7 entities in total)
• Functional Keywords: argonaute, rna interference, dna interference, nuclear protein-dna complex, nuclear protein/dna
• Biological source: Thermus thermophilus
• Total number of polymer chains: 8
• Total formula weight: 176908.60

Authors

Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Wang, Y. (deposition date: 2013-10-24, release date: 2014-01-15, Last modification date: 2023-02-01)

• Primary citation: Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Tian, W.,Swarts, D.C.,van der Oost, J.,Patel, D.J.,Wang, Y.; Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.; Proc.Natl.Acad.Sci.USA, 111:652-657, 2014; PubMed: 24374628; DOI: 10.1073/pnas.1321032111

Experimental method

X-RAY DIFFRACTION (2.489 Å)