4NB3

Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide

Summary for 4NB3

DescriptorReplication protein A 70 kDa DNA-binding subunit, 3,4 dichlorophenylalanine ATRIP derived peptide (3 entities in total)
Functional Keywords3, ob fold, protein-protein interaction, 4 dichlorophenylalanine, peptide binding protein
Biological sourceHomo sapiens (human)
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Cellular locationNucleus P27694
Total number of polymer chains4
Total molecular weight31395.78
Authors
Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Luzwik, J.W.,Cortez, D.,Olejniczak, O.T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-10-22, release date: 2014-02-26, Last modification date: 2014-04-09)
Primary citation
Frank, A.O.,Vangamudi, B.,Feldkamp, M.D.,Souza-Fagundes, E.M.,Luzwick, J.W.,Cortez, D.,Olejniczak, E.T.,Waterson, A.G.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.
Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.
J.Med.Chem., 57:2455-2461, 2014
PubMed: 24491171 (PDB entries with the same primary citation)
DOI: 10.1021/jm401730y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.17560.4%01.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4nb3
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Molmil generated image of 4nb3
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Molmil generated image of 4nb3
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More Biological unit images

Molmil generated image of 4nb3
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Molmil generated image of 4nb3
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Molmil generated image of 4nb3
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4nb3.pdb2.gz [54.57 KB])
Coordinate files for Biological unit (4nb3.pdb1.gz [54.47 KB])