4N9E

Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Summary for 4N9E

• Entry DOI: 10.2210/pdb4n9e/pdb
• Related: 4N9B 4N9C 4N9D
• Descriptor: Nicotinamide phosphoribosyltransferase, 1-[(1-benzoylpiperidin-4-yl)methyl]-N-(pyridin-3-yl)-1H-benzimidazole-5-carboxamide, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P43490
• Total number of polymer chains: 2
• Total formula weight: 116503.57

Authors

Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.,Hua, R.,Li, G.,Liang, X.,O'Brien, T.,Skelton, N.J.,Wang, C.,Zhao, Q.,Oh, A.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.,Zak, M.,Zheng, X. (deposition date: 2013-10-20, release date: 2014-02-19, Last modification date: 2024-02-28)

• Primary citation: Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X.; Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).; Bioorg.Med.Chem.Lett., 24:954-962, 2014; PubMed: 24433859; DOI: 10.1016/j.bmcl.2013.12.062

Experimental method

X-RAY DIFFRACTION (1.72 Å)