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4MRZ

Crystal structure of PDE10A2 with fragment ZT0429 (4-methyl-3-nitropyridin-2-amine)

Summary for 4MRZ
Entry DOI10.2210/pdb4mrz/pdb
Related4MRW 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4-methyl-3-nitropyridin-2-amine, NICKEL (II) ION, ... (4 entities in total)
Functional Keywordsfragment screening, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q9Y233
Total number of polymer chains2
Total formula weight79346.39
Authors
Sridhar, V.,Badger, J.,Logan, C.,Chie-Leon, B.,Nienaber, V. (deposition date: 2013-09-17, release date: 2014-05-14, Last modification date: 2023-09-20)
Primary citationRecht, M.I.,Sridhar, V.,Badger, J.,Bounaud, P.Y.,Logan, C.,Chie-Leon, B.,Nienaber, V.,Torres, F.E.
Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen, 19:497-507, 2014
Cited by
PubMed: 24375910
DOI: 10.1177/1087057113516493
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.58 Å)
Structure validation

217705

건을2024-03-27부터공개중

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