4M3Q

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917

Summary for 4M3Q

• Entry DOI: 10.2210/pdb4m3q/pdb
• Related: 2BRB 2POC 3BPR 3TCP
• Descriptor: Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: tyrosine kinase, acute lymphoblastic leukemia, rational structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane ; Single-pass type I membrane protein : Q12866
• Total number of polymer chains: 2
• Total formula weight: 72734.25

Authors

Zhang, W.,Zhang, D.,Stashko, M.A.,DeRyckere, D.,Hunter, D.,Kireev, D.B.,Miley, M.,Cummings, C.,Lee, M.,Norris-Drouin, J.,Stewart, W.M.,Sather, S.,Zhou, Y.,Kirkpatrick, G.,Machius, M.,Janzen, W.P.,Earp, H.S.,Graham, D.K.,Frye, S.,Wang, X. (deposition date: 2013-08-06, release date: 2013-11-27, Last modification date: 2023-09-20)

• Primary citation: Zhang, W.,Zhang, D.,Stashko, M.A.,Deryckere, D.,Hunter, D.,Kireev, D.,Miley, M.J.,Cummings, C.,Lee, M.,Norris-Drouin, J.,Stewart, W.M.,Sather, S.,Zhou, Y.,Kirkpatrick, G.,Machius, M.,Janzen, W.P.,Earp, H.S.,Graham, D.K.,Frye, S.V.,Wang, X.; Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.; J.Med.Chem., 56:9683-9692, 2013; PubMed: 24195762; DOI: 10.1021/jm401387j

Experimental method

X-RAY DIFFRACTION (2.718 Å)