4M2U
Carbonic Anhydrase II in complex with Dorzolamide
Summary for 4M2U
| Entry DOI | 10.2210/pdb4m2u/pdb |
| Related | 4M2R 4M2V 4M2W |
| Descriptor | Carbonic anhydrase 2, ZINC ION, (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, ... (4 entities in total) |
| Functional Keywords | lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29322.49 |
| Authors | Pinard, M.P.,Boone, C.D.,Rife, B.D.,Supuran, C.T.,Mckenna, R. (deposition date: 2013-08-05, release date: 2013-11-06, Last modification date: 2024-02-28) |
| Primary citation | Pinard, M.A.,Boone, C.D.,Rife, B.D.,Supuran, C.T.,McKenna, R. Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21:7210-7215, 2013 Cited by PubMed: 24090602DOI: 10.1016/j.bmc.2013.08.033 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.999 Å) |
Structure validation
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