4LUO

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

Summary for 4LUO

• Entry DOI: 10.2210/pdb4luo/pdb
• Related: 4LUV 4LUZ 4LW1 4LWC
• Descriptor: Replication protein A 70 kDa DNA-binding subunit, 1-(3-methylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (3 entities in total)
• Functional Keywords: ob-fold, protein-protein interaction, protein binding
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P27694
• Total number of polymer chains: 1
• Total formula weight: 14054.34

Authors

Feldkamp, M.D.,Frank, A.O.,Kennedy, J.P.,Waterson, A.G.,Olejniczak, E.T.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-07-25, release date: 2013-12-11, Last modification date: 2023-09-20)

• Primary citation: Frank, A.O.,Feldkamp, M.D.,Kennedy, J.P.,Waterson, A.G.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.; Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.; J.Med.Chem., 56:9242-9250, 2013; PubMed: 24147804; DOI: 10.1021/jm401333u

Experimental method

X-RAY DIFFRACTION (1.54 Å)