4LLD

Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A

Summary for 4LLD

• Entry DOI: 10.2210/pdb4lld/pdb
• Related: 4LLM 4LLQ 4LLU 4LLW 4LLY
• Descriptor: Ig gamma-1 chain C region, Ig lambda-2 chain C region (3 entities in total)
• Functional Keywords: igg domain, fragment of antibody, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01857
• Total number of polymer chains: 2
• Total formula weight: 25315.12

Authors

Pustilnik, A.,Lewis, S.M.,Wu, X.,Sereno, A.,Huang, F.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Kuhlman, B.,Demarest, S.J.,Atwell, S. (deposition date: 2013-07-09, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Lewis, S.M.,Wu, X.,Pustilnik, A.,Sereno, A.,Huang, F.,Rick, H.L.,Guntas, G.,Leaver-Fay, A.,Smith, E.M.,Ho, C.,Hansen-Estruch, C.,Chamberlain, A.K.,Truhlar, S.M.,Conner, E.M.,Atwell, S.,Kuhlman, B.,Demarest, S.J.; Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.; Nat.Biotechnol., 32:191-198, 2014; PubMed: 24463572; DOI: 10.1038/nbt.2797

Experimental method

X-RAY DIFFRACTION (1.19 Å)