4KW5

M. tuberculosis DprE1 in complex with inhibitor TCA1

Summary for 4KW5

Entry DOI	10.2210/pdb4kw5/pdb
Related	4FDN 4FDO 4FDP 4FEH 4FF6
Descriptor	Oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate, ... (6 entities in total)
Functional Keywords	alpha/beta fold, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	103107.27
Authors	Batt, S.M.,Besra, G.S.,Futterer, K. (deposition date: 2013-05-23, release date: 2013-07-10, Last modification date: 2023-09-20)
Primary citation	Wang, F.,Sambandan, D.,Halder, R.,Wang, J.,Batt, S.M.,Weinrick, B.,Ahmad, I.,Yang, P.,Zhang, Y.,Kim, J.,Hassani, M.,Huszar, S.,Trefzer, C.,Ma, Z.,Kaneko, T.,Mdluli, K.E.,Franzblau, S.,Chatterjee, A.K.,Johnson, K.,Mikusova, K.,Besra, G.S.,Futterer, K.,Jacobs, W.R.,Schultz, P.G. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc.Natl.Acad.Sci.USA, 110:E2510-E2517, 2013 Cited by PubMed: 23776209 DOI: 10.1073/pnas.1309171110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.612 Å)

Structure validation