4KSD

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Summary for 4KSD

• Entry DOI: 10.2210/pdb4ksd/pdb
• Related: 4KSB 4KSC 4LSG
• Descriptor: Multidrug resistance protein 1A, R2 protein (2 entities in total)
• Functional Keywords: transporter, atp binding, membrane, membrane protein, transport protein
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 155687.16

Authors

Ward, A.,Szewczyk, P.,Grimard, V.,Lee, C.-W.,Martinez, L.,Doshi, R.,Caya, A.,Villaluz, M.,Pardon, E.,Cregger, C.,Swartz, D.J.,Falson, P.,Urbatsch, I.,Govaerts, C.,Steyaert, J.,Chang, G. (deposition date: 2013-05-17, release date: 2013-07-31, Last modification date: 2019-07-17)

• Primary citation: Ward, A.B.,Szewczyk, P.,Grimard, V.,Lee, C.W.,Martinez, L.,Doshi, R.,Caya, A.,Villaluz, M.,Pardon, E.,Cregger, C.,Swartz, D.J.,Falson, P.G.,Urbatsch, I.L.,Govaerts, C.,Steyaert, J.,Chang, G.; Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.; Proc.Natl.Acad.Sci.USA, 110:13386-13391, 2013; PubMed: 23901103; DOI: 10.1073/pnas.1309275110

Experimental method

X-RAY DIFFRACTION (4.1001 Å)