4JX7

Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Summary for 4JX7

• Entry DOI: 10.2210/pdb4jx7/pdb
• Related: 4JX3
• Descriptor: Serine/threonine-protein kinase pim-1, PIM1 consensus peptide, 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one, ... (4 entities in total)
• Functional Keywords: serine/threonine-protein kinases, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 2
• Total formula weight: 39304.68

Authors

Lee, S.J.,Han, B.G.,Cho, J.W.,Choi, J.S.,Lee, J.K.,Song, H.J.,Koh, J.S.,Lee, B.I. (deposition date: 2013-03-27, release date: 2013-08-28, Last modification date: 2023-09-20)

• Primary citation: Lee, S.J.,Han, B.G.,Cho, J.W.,Choi, J.S.,Lee, J.,Song, H.J.,Koh, J.S.,Lee, B.I.; Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.; Plos One, 8:e70358-e70358, 2013; PubMed: 23936194; DOI: 10.1371/journal.pone.0070358

Experimental method

X-RAY DIFFRACTION (2.4 Å)