4JVE

Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid

Summary for 4JVE

Entry DOI	10.2210/pdb4jve/pdb
Related	4JV7 4JV9 4JVR 4JWR
Descriptor	E3 ubiquitin-protein ligase Mdm2, (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid (3 entities in total)
Functional Keywords	p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	1
Total formula weight	11684.45
Authors	Huang, X.,Gonzalez-Lopez de Turiso, F.,Sun, D.,Yosup, R.,Bartberger, M.D.,Beck, H.P.,Cannon, J.,Shaffer, P.,Oliner, J.D.,Olson, S.H.,Medina, J.C. (deposition date: 2013-03-25, release date: 2013-05-01, Last modification date: 2013-06-05)
Primary citation	Gonzalez-Lopez de Turiso, F.,Sun, D.,Rew, Y.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Correll, T.L.,Huang, X.,Julian, L.D.,Kayser, F.,Lo, M.C.,Long, A.M.,McMinn, D.,Oliner, J.D.,Osgood, T.,Powers, J.P.,Saiki, A.Y.,Schneider, S.,Shaffer, P.,Xiao, S.H.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H. Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56:4053-4070, 2013 Cited by PubMed: 23597064 DOI: 10.1021/jm400293z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation