4JPW

Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant

Summary for 4JPW

• Entry DOI: 10.2210/pdb4jpw/pdb
• Related: 3NGB 3SE8 3SE9 4GW4 4JPV
• Descriptor: HIV-1 CLADE A/E STRAIN 73TH057 GP120 WITH MUTATION H375S, HEAVY CHAIN OF ANTIBODY 12A21, LIGHT CHAIN OF ANTIBODY 12A21, ... (6 entities in total)
• Functional Keywords: hiv, gp120, cd4-binding site, 12a21, neutralization, vaccine, antibody, envelope protein, viral protein-immune system complex, viral protein/immune system
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1; More
• Total number of polymer chains: 3
• Total formula weight: 88912.82

Authors

Acharya, P.,Luongo, T.,Zhou, T.,Kwong, P.D. (deposition date: 2013-03-19, release date: 2013-04-17, Last modification date: 2023-09-20)

• Primary citation: Klein, F.,Diskin, R.,Scheid, J.F.,Gaebler, C.,Mouquet, H.,Georgiev, I.S.,Pancera, M.,Zhou, T.,Incesu, R.B.,Fu, B.Z.,Gnanapragasam, P.N.,Oliveira, T.Y.,Seaman, M.S.,Kwong, P.D.,Bjorkman, P.J.,Nussenzweig, M.C.; Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.; Cell(Cambridge,Mass.), 153:126-138, 2013; PubMed: 23540694; DOI: 10.1016/j.cell.2013.03.018

Experimental method

X-RAY DIFFRACTION (2.904 Å)