4JAN

crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120

Summary for 4JAN

• Entry DOI: 10.2210/pdb4jan/pdb
• Related: 4J6R 4JAM 4JB9
• Descriptor: ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ... (7 entities in total)
• Functional Keywords: hiv-1, gp120, glycoprotein, viral protein-immune system complex, antibody, immunoglobulin, neutralization, vaccine, viral protein/immune system
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1; More
• Total number of polymer chains: 6
• Total formula weight: 173850.40

Authors

Zhou, T.,Moquin, S.,Zheng, A.,Srivatsan, S.,Kwong, P.D. (deposition date: 2013-02-18, release date: 2013-04-03, Last modification date: 2023-09-20)

• Primary citation: Liao, H.X.,Lynch, R.,Zhou, T.,Gao, F.,Alam, S.M.,Boyd, S.D.,Fire, A.Z.,Roskin, K.M.,Schramm, C.A.,Zhang, Z.,Zhu, J.,Shapiro, L.,Mullikin, J.C.,Gnanakaran, S.,Hraber, P.,Wiehe, K.,Kelsoe, G.,Yang, G.,Xia, S.M.,Montefiori, D.C.,Parks, R.,Lloyd, K.E.,Scearce, R.M.,Soderberg, K.A.,Cohen, M.,Kamanga, G.,Louder, M.K.,Tran, L.M.,Chen, Y.,Cai, F.,Chen, S.,Moquin, S.,Du, X.,Joyce, M.G.,Srivatsan, S.,Zhang, B.,Zheng, A.,Shaw, G.M.,Hahn, B.H.,Kepler, T.B.,Korber, B.T.,Kwong, P.D.,Mascola, J.R.,Haynes, B.F.; Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.; Nature, 496:469-476, 2013; PubMed: 23552890; DOI: 10.1038/nature12053

Experimental method

X-RAY DIFFRACTION (3.15 Å)