4JAI

Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide

4JAI の概要

• エントリーDOI: 10.2210/pdb4jai/pdb
• 関連するPDBエントリー: 4JAJ
• 分子名称: Aurora kinase A, N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide (3 entities in total)
• 機能のキーワード: kinase inhibitor complex, atp-binding, cell cycle, cytoplasm, cytoskeleton, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, protein kinase-like, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33451.33

構造登録者

Jiang, X.,Josephson, K.,Huck, B.,Goutopoulos, A.,Karra, S. (登録日: 2013-02-18, 公開日: 2013-05-22, 最終更新日: 2023-09-20)

• 主引用文献: Karra, S.,Xiao, Y.,Chen, X.,Liu-Bujalski, L.,Huck, B.,Sutton, A.,Goutopoulos, A.,Askew, B.,Josephson, K.,Jiang, X.,Shutes, A.,Shankar, V.,Noonan, T.,Garcia-Berrios, G.,Dong, R.,Dhanabal, M.,Tian, H.,Wang, Z.,Clark, A.,Goodstal, S.; SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.; Bioorg.Med.Chem.Lett., 23:3081-3087, 2013; PubMed: 23570792; DOI: 10.1016/j.bmcl.2013.03.008

実験手法

X-RAY DIFFRACTION (3.2 Å)