4J50

Crystal Structure of an Expanded RNA CAG Repeat

Summary for 4J50

• Entry DOI: 10.2210/pdb4j50/pdb
• Descriptor: RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3'), PHOSPHATE ION (3 entities in total)
• Functional Keywords: a form rna, cag repeat expansion, polyq, gain of rna function, huntingtin disease, spinal-bulbar muscular atrophy, dentatorubral-pallidoluysian atrophy, spinocerebellar ataxia, rna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 12407.32

Authors

Park, H.,Disney, M.D. (deposition date: 2013-02-07, release date: 2013-02-20, Last modification date: 2024-02-28)

• Primary citation: Yildirim, I.,Park, H.,Disney, M.D.,Schatz, G.C.; A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.; J.Am.Chem.Soc., 135:3528-3538, 2013; PubMed: 23441937; DOI: 10.1021/ja3108627

Experimental method

X-RAY DIFFRACTION (1.65 Å)