4J3J

Crystal Structure of DPP-IV with Compound C3

Summary for 4J3J

Entry DOI	10.2210/pdb4j3j/pdb
Descriptor	Dipeptidyl peptidase 4, N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide (2 entities in total)
Functional Keywords	inhibitor complex, serine exopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P27487
Total number of polymer chains	2
Total formula weight	169793.99
Authors	Xiong, B.,Zhu, L.R.,Chen, D.Q.,Zhao, Y.L.,Jiang, F.,Shen, J.K. (deposition date: 2013-02-05, release date: 2014-02-05, Last modification date: 2023-11-08)
Primary citation	Zhu, L.,Li, Y.,Qiu, L.,Su, M.,Wang, X.,Xia, C.,Qu, Y.,Li, J.,Li, J.,Xiong, B.,Shen, J. Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors Chemmedchem, 8:1104-1116, 2013 Cited by PubMed: 23671024 DOI: 10.1002/cmdc.201300104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation