4IXV

Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)

Summary for 4IXV

Entry DOI	10.2210/pdb4ixv/pdb
Related	1D3V 1PQ3 4IXU
Descriptor	Arginase-2, mitochondrial, MANGANESE (II) ION, BENZAMIDINE, ... (6 entities in total)
Functional Keywords	metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, mitochondrion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens
Cellular location	Mitochondrion : P78540
Total number of polymer chains	3
Total formula weight	101818.54
Authors	Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Whitehouse, D.,Beckett, P.,Van Zandt, M.C.,Ji, M.K.,Ryder, T.,Jagdmann, R.,Andreoli, M.,Olczak, J.,Mazur, M.,Czestkowski, W.,Piotrowska, W.,Schroeter, H.,Golebiowski, A.,Podjarny, A. (deposition date: 2013-01-28, release date: 2013-12-11, Last modification date: 2023-09-20)
Primary citation	Golebiowski, A.,Whitehouse, D.,Beckett, R.P.,Van Zandt, M.,Ji, M.K.,Ryder, T.R.,Jagdmann, E.,Andreoli, M.,Lee, Y.,Sheeler, R.,Conway, B.,Olczak, J.,Mazur, M.,Czestkowski, W.,Piotrowska, W.,Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Podjarny, A.,Schroeter, H. Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg.Med.Chem.Lett., 23:4837-4841, 2013 Cited by PubMed: 23886684 DOI: 10.1016/j.bmcl.2013.06.092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation