4IUI
Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY derivative, 4a
Summary for 4IUI
Entry DOI | 10.2210/pdb4iui/pdb |
Related | 4IU7 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, 4-[1-butyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor, transcription factor, ligand binding, nucleus, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 59632.19 |
Authors | Nwachukwu, J.C.,Srinivasan, S.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2013-01-21, release date: 2013-03-27, Last modification date: 2023-09-20) |
Primary citation | Srinivasan, S.,Nwachukwu, J.C.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W. Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha Nat.Chem.Biol., 9:326-332, 2013 Cited by PubMed: 23524984DOI: 10.1038/nchembio.1214 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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