4IKT

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine

Summary for 4IKT

Entry DOI	10.2210/pdb4ikt/pdb
Related	4IKR 4IKS 4IKU
Descriptor	Methionine aminopeptidase 1, N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine, COBALT (II) ION, ... (6 entities in total)
Functional Keywords	pita-bread fold, aminopeptidase, ribosome, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37652.72
Authors	Addlagatta, A.,Kishor, C.,Arya, T. (deposition date: 2012-12-28, release date: 2013-12-11, Last modification date: 2024-03-20)
Primary citation	Kishor, C.,Arya, T.,Reddi, R.,Chen, X.,Saddanapu, V.,Marapaka, A.K.,Gumpena, R.,Ma, D.,Liu, J.O.,Addlagatta, A. Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases J.Med.Chem., 56:5295-5305, 2013 Cited by PubMed: 23767698 DOI: 10.1021/jm400395p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation