4IB4

Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine

Summary for 4IB4

• Entry DOI: 10.2210/pdb4ib4/pdb
• Descriptor: Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, Ergotamine, PALMITIC ACID, ... (9 entities in total)
• Functional Keywords: ergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : P41595
• Total number of polymer chains: 1
• Total formula weight: 51711.33

Authors

Wacker, D.,Wang, C.,Katritch, V.,Han, G.W.,Huang, X.,Vardy, E.,McCorvy, J.D.,Jiang, Y.,Chu, M.,Siu, F.Y.,Liu, W.,Xu, H.E.,Cherezov, V.,Roth, B.L.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2012-12-07, release date: 2013-03-13, Last modification date: 2023-09-20)

• Primary citation: Wacker, D.,Wang, C.,Katritch, V.,Han, G.W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Jiang, Y.,Chu, M.,Siu, F.Y.,Liu, W.,Xu, H.E.,Cherezov, V.,Roth, B.L.,Stevens, R.C.; Structural features for functional selectivity at serotonin receptors.; Science, 340:615-619, 2013; PubMed: 23519215; DOI: 10.1126/science.1232808

Experimental method

X-RAY DIFFRACTION (2.7 Å)