4IAO

Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4

Summary for 4IAO

Entry DOI	10.2210/pdb4iao/pdb
Descriptor	NAD-dependent histone deacetylase SIR2, Regulatory protein SIR4, ZINC ION, ... (5 entities in total)
Functional Keywords	protein complex, sir2, deacetylase, nucleus, hydrolase-transcription complex, hydrolase/transcription
Biological source	Saccharomyces cerevisiae More
Cellular location	Nucleus, nucleolus: P06700 Nucleus: P11978
Total number of polymer chains	4
Total formula weight	148706.89
Authors	Hsu, H.C.,Wang, C.L.,Wang, M.,Yang, N.,Chen, Z.,Sternglanz, R.,Xu, R.M. (deposition date: 2012-12-07, release date: 2012-12-26, Last modification date: 2024-03-20)
Primary citation	Hsu, H.C.,Wang, C.L.,Wang, M.,Yang, N.,Chen, Z.,Sternglanz, R.,Xu, R.M. Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding Genes Dev., 27:64-73, 2013 Cited by PubMed: 23307867 DOI: 10.1101/gad.208140.112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.901 Å)

Structure validation