4I87
Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH
Summary for 4I87
| Entry DOI | 10.2210/pdb4i87/pdb |
| Related | 4I85 4I89 |
| Descriptor | Transthyretin, 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid (3 entities in total) |
| Functional Keywords | transthyretin, amyloidosis, fibrillogenesis inhibitors, protein misfolding, t3 or t4 hormone, plasma, transport protein-inhibitor complex, transport protein/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28152.88 |
| Authors | Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. (deposition date: 2012-12-03, release date: 2013-06-19, Last modification date: 2023-09-20) |
| Primary citation | Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors. Febs Lett., 587:2325-2331, 2013 Cited by PubMed: 23792159DOI: 10.1016/j.febslet.2013.06.016 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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