4I43

Crystal structure of Prp8:Aar2 complex

Summary for 4I43

• Entry DOI: 10.2210/pdb4i43/pdb
• Related: 3ZEF
• Descriptor: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 (3 entities in total)
• Functional Keywords: spliceosome, u5 snrnp, prp8, reverse transcriptase, aar2, endonuclease, rnase h, jab1/mpn, pre-mrna splicing, splicing
• Biological source: Saccharomyces cerevisiae (yeast); More
• Cellular location: Cytoplasm: P32357; Nucleus : P33334
• Total number of polymer chains: 2
• Total formula weight: 225184.79

Authors

Galej, W.P.,Oubridge, C.,Newman, A.J.,Nagai, K. (deposition date: 2012-11-27, release date: 2013-01-23, Last modification date: 2023-09-20)

• Primary citation: Galej, W.P.,Oubridge, C.,Newman, A.J.,Nagai, K.; Crystal structure of Prp8 reveals active site cavity of the spliceosome.; Nature, 493:638-643, 2013; PubMed: 23354046; DOI: 10.1038/nature11843

Experimental method

X-RAY DIFFRACTION (2 Å)