Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221

Summary for 4I3R

Related3se9 3ngb 3se8 3tyg 4I3S
DescriptorOuter domain of HIV-1 gp120 (KER2018 OD4.2.2), Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... (5 entities in total)
Functional Keywordsantibody affinity, antibody specificity, binding sites, hiv infections, antibodies, hiv envelope protein gp120, aids vaccines, amino acid sequence, antigens, epitopes, hiv antibodies, cd4, somatic mutation, sequence engineering, complementarity determining regions, immunoglobulin fab fragments, sera, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman Immunodeficiency Virus
Total number of polymer chains3
Total molecular weight69377.6
Joyce, M.G.,Biertumpfel, C.,Nabel, G.J.,Kwong, P.D. (deposition date: 2012-11-26, release date: 2013-01-09, Last modification date: 2013-02-13)
Primary citation
Joyce, M.G.,Kanekiyo, M.,Xu, L.,Biertumpfel, C.,Boyington, J.C.,Moquin, S.,Shi, W.,Wu, X.,Yang, Y.,Yang, Z.Y.,Zhang, B.,Zheng, A.,Zhou, T.,Zhu, J.,Mascola, J.R.,Kwong, P.D.,Nabel, G.J.
Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87:2294-2306, 2013
PubMed: 23236069 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.02717-12
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247100.3%10.0%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report