4I2L

New HIV entry inhibitor MTSFT/T23 complex

Summary for 4I2L

• Entry DOI: 10.2210/pdb4i2l/pdb
• Descriptor: GP41, inhibitor MTSFT (3 entities in total)
• Functional Keywords: 6-helix bundle, coiled-coil, membrane, fusion inhibitor, m-t hook, 6-helix-bundle, tryptophan-methionine, viral protein-antiviral protein complex, viral protein/antiviral protein
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P04580
• Total number of polymer chains: 2
• Total formula weight: 9651.84

Authors

Yao, X.,Chong, H.H.,Waltersperger, S.,Wang, M.T.,He, Y.X.,Cui, S. (deposition date: 2012-11-22, release date: 2014-01-22, Last modification date: 2023-11-08)

• Primary citation: Yao, X.,Chong, H.H.,Waltersperger, S.,Wang, M.T.,He, Y.X.,Cui, S.; Potent antiviral activity of the novel HIV entry inhibitor MTSFT; To be Published,

Experimental method

X-RAY DIFFRACTION (1.426 Å)