4HZS

Crystal structure of Ack1 kinase domain with C-terminal SH3 domain

Summary for 4HZS

• Entry DOI: 10.2210/pdb4hzs/pdb
• Related: 4HZR
• Descriptor: Activated CDC42 kinase 1 (1 entity in total)
• Functional Keywords: inactive state, allostery, dimerization, oligomerization, negative regulation, activation, phosphotransfer, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane: Q07912
• Total number of polymer chains: 4
• Total formula weight: 155446.11

Authors

Gajiwala, K.S. (deposition date: 2012-11-15, release date: 2013-02-06, Last modification date: 2024-02-28)

• Primary citation: Gajiwala, K.S.,Maegley, K.,Ferre, R.,He, Y.A.,Yu, X.; Ack1: activation and regulation by allostery.; Plos One, 8:e53994-e53994, 2013; PubMed: 23342057; DOI: 10.1371/journal.pone.0053994

Experimental method

X-RAY DIFFRACTION (3.23 Å)