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4HW3

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Summary for 4HW3
Entry DOI10.2210/pdb4hw3/pdb
Related4HW2 4HW4
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1, 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid (3 entities in total)
Functional Keywordsregulation of apoptosis, maintenance of viability, apoptosis, apoptosis-inhibitor complex, apoptosis/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass membrane protein (Potential): Q07820
Total number of polymer chains12
Total formula weight214425.44
Authors
Zhao, B. (deposition date: 2012-11-07, release date: 2013-01-09, Last modification date: 2024-02-28)
Primary citationFriberg, A.,Vigil, D.,Zhao, B.,Daniels, R.N.,Burke, J.P.,Garcia-Barrantes, P.M.,Camper, D.,Chauder, B.A.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56:15-30, 2013
Cited by
PubMed: 23244564
DOI: 10.1021/jm301448p
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

건을2024-03-27부터공개중

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