4HTX

Crystal structure of PDE2 catalytic domain in complex with BAY60-7550

Summary for 4HTX

• Entry DOI: 10.2210/pdb4htx/pdb
• Related: 4HTZ
• Descriptor: cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Isoform PDE2A3: Cell membrane ; Lipid-anchor . Isoform PDE2A2: Mitochondrion matrix . Isoform PDE2A1: Cytoplasm . Isoform 5: Mitochondrion : O00408
• Total number of polymer chains: 4
• Total formula weight: 162128.23

Authors

Zhu, J.,Huang, Q. (deposition date: 2012-11-02, release date: 2013-08-28, Last modification date: 2023-09-20)

• Primary citation: Zhu, J.,Yang, Q.,Dai, D.,Huang, Q.; X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity.; J.Am.Chem.Soc., 135:11708-11711, 2013; PubMed: 23899287; DOI: 10.1021/ja404449g

Experimental method

X-RAY DIFFRACTION (1.9 Å)