4HGL

Crystal structure of ck1g3 with compound 1

Summary for 4HGL

• Entry DOI: 10.2210/pdb4hgl/pdb
• Related: 4G16 4G17 4HGS 4HGT
• Descriptor: Casein kinase I isoform gamma-3, 2-[5-methoxy-2-(quinolin-3-yl)pyrimidin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: ck1g, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9Y6M4
• Total number of polymer chains: 1
• Total formula weight: 38936.68

Authors

Huang, X. (deposition date: 2012-10-08, release date: 2012-11-21, Last modification date: 2024-02-28)

• Primary citation: Huang, H.,Acquaviva, L.,Berry, V.,Bregman, H.,Chakka, N.,O'Connor, A.,DiMauro, E.F.,Dovey, J.,Epstein, O.,Grubinska, B.,Goldstein, J.,Gunaydin, H.,Hua, Z.,Huang, X.,Huang, L.,Human, J.,Long, A.,Newcomb, J.,Patel, V.F.,Saffran, D.,Serafino, R.,Schneider, S.,Strathdee, C.,Tang, J.,Turci, S.,White, R.,Yu, V.,Zhao, H.,Wilson, C.,Martin, M.W.; Structure-Based Design of Potent and Selective CK1 gamma Inhibitors.; ACS Med Chem Lett, 3:1059-1064, 2012; PubMed: 24900428; DOI: 10.1021/ml300278f

Experimental method

X-RAY DIFFRACTION (2.4 Å)