4HEU
Crystal Structure of PDE10A with a biaryl ether inhibitor ((1-(3-(4-((1H-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol)
Summary for 4HEU
Entry DOI | 10.2210/pdb4heu/pdb |
Related | 4DDL 4HF4 |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | pde10a, inhibitors, phosphodiesterase 10a, biaryl ethers, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 75960.25 |
Authors | |
Primary citation | Rzasa, R.M.,Hu, E.,Rumfelt, S.,Chen, N.,Andrews, K.L.,Chmait, S.,Falsey, J.R.,Zhong, W.,Jones, A.D.,Porter, A.,Louie, S.W.,Zhao, X.,Treanor, J.J.,Allen, J.R. Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux. Bioorg.Med.Chem.Lett., 22:7371-7375, 2012 Cited by PubMed: 23149228DOI: 10.1016/j.bmcl.2012.10.078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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