4HBM

Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors

Summary for 4HBM

• Entry DOI: 10.2210/pdb4hbm/pdb
• Related: 4ERE 4ERF
• Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid (3 entities in total)
• Functional Keywords: mdm2, p53, protein protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 8
• Total formula weight: 112367.06

Authors

Huang, X. (deposition date: 2012-09-28, release date: 2012-10-17, Last modification date: 2024-02-28)

• Primary citation: Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L.; Ordering of the N-terminus of human MDM2 by small molecule inhibitors.; J.Am.Chem.Soc., 134:17059-17067, 2012; PubMed: 22991965; DOI: 10.1021/ja305839b

Experimental method

X-RAY DIFFRACTION (1.9 Å)