4HB4

Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1

Summary for 4HB4

Entry DOI	10.2210/pdb4hb4/pdb
Related	4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3
Descriptor	GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total)
Functional Keywords	heat repeat, nuclear export, ran-ranbp1, lmb, leptomycin b, protein transport-antibiotic complex, protein transport/antibiotic
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : P62826 P30822 Cytoplasm: P41920
Total number of polymer chains	3
Total formula weight	159669.96
Authors	Sun, Q.,Chook, Y.M. (deposition date: 2012-09-27, release date: 2013-01-09, Last modification date: 2017-07-26)
Primary citation	Sun, Q.,Carrasco, Y.P.,Hu, Y.,Guo, X.,Mirzaei, H.,Macmillan, J.,Chook, Y.M. Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110:1303-1308, 2013 Cited by PubMed: 23297231 DOI: 10.1073/pnas.1217203110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation