4H6J

Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.

Summary for 4H6J

• Entry DOI: 10.2210/pdb4h6j/pdb
• Related: 3F1P
• Descriptor: HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR (3 entities in total)
• Functional Keywords: pas domain, heterodimer, hypoxia inducible factor, transcription factor, arnt, transcription
• Biological source: Homo sapiens; More
• Cellular location: Cytoplasm : Q16665; Nucleus: P27540
• Total number of polymer chains: 2
• Total formula weight: 26692.05

Authors

Cardoso, R.,Love, R.A.,Nilsson, C.,Bergqvist, S.,Nowlin, D.,Yan, J.,Liu, K.,Zhu, J.,Chen, P.,Deng, Y.-L.,Dyson, H.J.,Greig, M.J.,Brooun, A. (deposition date: 2012-09-19, release date: 2012-12-05, Last modification date: 2024-02-28)

• Primary citation: Cardoso, R.,Love, R.,Nilsson, C.L.,Bergqvist, S.,Nowlin, D.,Yan, J.,Liu, K.K.,Zhu, J.,Chen, P.,Deng, Y.L.,Dyson, H.J.,Greig, M.J.,Brooun, A.; Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.; Protein Sci., 21:1885-1896, 2012; PubMed: 23033253; DOI: 10.1002/pro.2172

Experimental method

X-RAY DIFFRACTION (1.52 Å)