4GT7

An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, non-receptor binding conformation

Summary for 4GT7

• Entry DOI: 10.2210/pdb4gt7/pdb
• Descriptor: Ig epsilon chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: immunoglobulin, antibody, ige, fc fragment, immune system, fc receptor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 102360.71

Authors

Wurzburg, B.A.,Kim, B.K.,Jardetzky, T.S. (deposition date: 2012-08-28, release date: 2012-09-12, Last modification date: 2020-07-29)

• Primary citation: Wurzburg, B.A.,Kim, B.,Tarchevskaya, S.S.,Eggel, A.,Vogel, M.,Jardetzky, T.S.; An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation.; J.Biol.Chem., 287:36251-36257, 2012; PubMed: 22948141; DOI: 10.1074/jbc.M112.407502

Experimental method

X-RAY DIFFRACTION (2.61 Å)