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4GMY

JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE

Summary for 4GMY
Entry DOI10.2210/pdb4gmy/pdb
Related4GFM 4GFO 4GIH
DescriptorTyrosine-protein kinase JAK2, 2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide (3 entities in total)
Functional Keywordsjak2, jh1 kinase domain, tyrosine kinase, phosphotransferase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndomembrane system; Peripheral membrane protein (By similarity): O60674
Total number of polymer chains1
Total formula weight35836.45
Authors
Murray, J.M.,Shia, S. (deposition date: 2012-08-16, release date: 2013-06-19, Last modification date: 2013-08-07)
Primary citationLiang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S.
Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67:175-187, 2013
Cited by
PubMed: 23867602
DOI: 10.1016/j.ejmech.2013.03.070
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.403 Å)
Structure validation

218500

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